Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors depending on each SARM’s chemical structure. Consequently, SARMs lead to anabolic cellular activity while avoiding many of the side effects of now available steroids. SARMs are already studied in the treating breast cancer and cachexia and have already been utilized as performance-enhancing agents. Here, we evaluate and summarize the actual literature on SARMs.
Aim
To present the setting, mechanisms, current and potential clinical applications, as well as risks and benefits of SARMs.
Methods
A literature review was performed in MEDLINE while using terms selective androgen receptor modulator, hypogonadism, cachexia, breast cancer, benign prostatic hyperplasia, libido, and lean muscle mass. Both preliminary research and studies were included.
Main Outcome Measure
To complete an assessment peer-reviewed literature.
Results
Nevertheless, there are presently no U.S. Food and Drug Agency-approved indications for SARMs, investigators are exploring the potential ways to use these compounds. Investigation has centered on the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability with a paucity of drug interactions. Early clinical studies have demonstrated potential uses for SARMs from the treatments for cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and breast cancers, with results.
Conclusion
SARMs have a lot of possible clinical applications, with promise for that safe use within the management of cachexia, BPH, hypogonadism, breast cancers, and cancer of the prostate.
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