SINCE World War II, medical science has progressed to some stage where competitive medications are available to treat exactly the same ailment in various people. This is simply not almost brands (which is a trade issue) but generic drugs (which is a scientific issue). On this report, we shall glance at the various factors that decide your selection of a particular drug.
Safety: The subsequent sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug even though it has certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers are incredible in healing pain but include the possibility side-effect of addiction.
* Long-term safety: medicationdirectory.com could possibly be safe in short-term treatment, so how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals respond to create a different chemical, that have an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to generate a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of one another, have certain effects on a single or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This will cause a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually generate the same relation to exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the medicines are more serious.
Tolerability: A drug could possibly be effective and not tolerable by all patients. Example: Allergies to certain drugs in certain people. Short-term and long-term tolerability should be considered. Efficacy: A drug just isn’t equally efficient at all patients. As an example, some patients with depression or panic attacks experience reduced escitalopram, but there are numerous who don’t, who therefore should be prescribed a different anti-depressant. The speed of start of therapeutic action is a crucial step to be considered too.
Cost: Cost does not mean the expense of acquisition of a specific medicine alone. It will also cover the expense of management of a complication that will arise by using a different drug. Example: In the individual who insists on taking alcohol nevertheless has to be treated for depression is often administered an SSRI drug because these drugs don’t potentiate the end results of alcohol, whereas another group of anti-depressants (like tricyclics) may cause a whole new condition in such patients, which may need a various and expensive treatment. Therefore, it’s safer to prescribe the more expensive escitalopram rather than cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. When there is a selection between an injection and oral administration, the second is preferred when the efficacy of the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to make a decision simple treatment.
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