Selective androgen receptor modulators (SARMs) differentially bind to androgen receptors based on each SARM’s chemical structure. Because of this, SARMs result in anabolic cellular activity while avoiding most of the unwanted effects of currently available anabolic steroids. SARMs have been studied from the treatment of breast cancers and cachexia and still have been used as performance-enhancing agents. Here, we evaluate and summarize the present literature on SARMs.
Aim
To present the backdrop, mechanisms, current and potential clinical applications, as well as risks and great things about SARMs.
Methods
A literature review was performed in MEDLINE using the terms selective androgen receptor modulator, hypogonadism, cachexia, cancer of the breast, benign prostatic hyperplasia, libido, and muscle. Both basic research and clinical studies were included.
Main Outcome Measure
To complete an assessment of peer-reviewed literature.
Results
However, there are no U.S. Drug and food Agency-approved indications for SARMs, investigators are exploring the potential ways to use these compounds. Basic research has focused on the pharmacokinetics and pharmacodynamics of such agents, demonstrating good availability using a paucity of drug interactions. Early clinical studies have demonstrated potential uses for SARMs inside the treatments for cancer-related cachexia, benign prostatic hyperplasia (BPH), hypogonadism, and cancer of the breast, with good results.
Conclusion
SARMs have numerous possible clinical applications, with promise for the safe utilization in the treating cachexia, BPH, hypogonadism, breast cancers, and cancer of the prostate.
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