SINCE Wwii, medical science has progressed with a stage where competitive medications are around to treat precisely the same ailment in various people. It’s not pretty much brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall look at the various factors that decide the selection of a specific drug.
Safety: The subsequent sub-criteria has to be considered beneath the criterion of safety:
* Acute therapeutic index: In the event the patient’s condition is acute, how effective can be a particular drug even when it has certain side-effects so long as the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but include the possible side-effect of addiction.
* Long-term safety: drug might be safe in short-term treatment, so how safe it really is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but could have undesirable effects in the event of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and lots of chemicals answer produce a different chemical, which has an effect that will harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to make a new condition that warrants separate treatment.
Drug-drug interaction risk is of two sorts:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other person, have certain effects one or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon because of its metabolism. This leads to an increase in the side-effects of Lexapro.
· Pharmacodynamic: Here, several drugs actually generate the same influence on precisely the same organ, thus enhancing the total, added effect. Example: Lexapro has certain side-effects for example drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the drugs are more intense.
Tolerability: A medication might be effective however, not tolerable by all patients. Example: Allergies to certain drugs in most people. Short-term and long-term tolerability must be considered. Efficacy: A medication is just not equally efficient at all patients. For example, some patients with depression or panic attacks experience rest from escitalopram, but there are several that don’t, who therefore must be prescribed a different anti-depressant. The pace of start of therapeutic action is a vital step to be looked at too.
Cost: Cost does not necessarily mean the expense of acquisition of some medicine alone. It must also cover the expense of management of a complication that will arise from using a different drug. Example: In the individual that insists on taking alcohol nevertheless must be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the consequences of alcohol, whereas another band of anti-depressants (for example tricyclics) might cause a whole new problem in such patients, which would have to have a different and expensive treatment. Therefore, it’s safer to prescribe the more costly escitalopram rather than a cheaper tricyclic in this patients.
Simplicity of treatment: The easiest mode of administration is preferred. When there is a selection between a shot and oral administration, aforementioned is preferred if your efficacy of the modes is comparable. Or, local application is preferred to the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to determine simplicity of treatment.
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