SINCE The second world war, medical science has progressed with a stage where competitive medications are around to treat the same ailment in several people. This isn’t almost brands (that is a trade issue) but generic drugs (that is a scientific issue). Within this report, we shall go through the various factors that decide selecting a selected drug.
Safety: These sub-criteria should be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective can be a particular drug regardless of whether they have certain side-effects provided that the acuteness with the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but come with the potential side-effect of addiction.
* Long-term safety: medication may be safe in short-term treatment, but wait, how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but can have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals respond to create a different chemical, that have an effect that will harm the patient or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two kinds:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, outside of the other person, have certain effects using one or even more body processes (e.g., metabolism) that affects the performance with the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends upon due to the metabolism. This leads to a boost in the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually produce the same influence on the same organ, thus improving the total, added effect. Example: Lexapro has certain side-effects including drowsiness and fatigue. Darvocet-N also acts similarly for the brain. Thus, the side-effects of the medicines are more serious.
Tolerability: A drug may be effective although not tolerable by all patients. Example: Allergies to specific drugs in some people. Short-term and long-term tolerability need to be considered. Efficacy: A drug is just not equally great at all patients. For example, some patients with depression or anxiety attacks experience reduced escitalopram, but there are lots of that do not, who therefore need to be prescribed some other anti-depressant. The rate of onset of therapeutic action is a factor to be looked at too.
Cost: Cost doesn’t imply the cost of buying a particular medicine alone. It must also cover the cost of treating a complication that will arise by using some other drug. Example: In the individual who insists on taking alcohol nevertheless has to be treated for depression is generally administered an SSRI drug as these drugs don’t potentiate the effects of alcohol, whereas another number of anti-depressants (including tricyclics) could cause a brand new symptom in such patients, which will require a different and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram instead of a cheaper tricyclic in this patients.
Simplicity of treatment: The simplest mode of administration is preferred. If there is a choice between an injection and oral administration, rogues is preferred in the event the efficacy of the modes is the identical. Or, local application is preferred to the oral route where possible; e.g., antibiotic treating eye infections. Dosage and frequency of administration too are a key factor to make a decision simple treatment.
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