SINCE World war 2, medical science has progressed to a stage where competitive medications are available to treat the same ailment in different people. This is simply not just about brands (that is a trade issue) but generic drugs (that is a scientific issue). On this report, we shall glance at the various factors that decide picking a a specific drug.
Safety: The next sub-criteria have to be considered beneath the criterion of safety:
* Acute therapeutic index: If the patient’s condition is acute, how effective is really a particular drug even though it’s certain side-effects provided that the acuteness in the condition is lowered? Example: narcotic pain-killers are amazing in healing pain but include the opportunity side-effect of addiction.
* Long-term safety: medication could possibly be safe in short-term treatment, but how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and several chemicals answer create a different chemical, which has an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of 2 types:
· Pharmacokinetic: In this type of drug-drug interaction, two drugs, separate from the other, have certain effects on a single or maybe more body processes (e.g., metabolism) that affects the performance in the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This will cause a rise in the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually produce the same relation to the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of the two medicine is more serious.
Tolerability: A medication could possibly be effective although not tolerable by all patients. Example: Allergies to particular drugs in certain people. Short-term and long-term tolerability should be taken into consideration. Efficacy: A medication isn’t equally effective in all patients. As an example, some patients with depression or panic disorders experience relief from escitalopram, but there are lots of that do not, who therefore should be prescribed an alternative anti-depressant. The interest rate of oncoming of therapeutic action is a vital key to be regarded too.
Cost: Cost does not mean the expense of acquiring some medicine alone. It must also cover the expense of treatments for a complication which could arise from using an alternative drug. Example: Within a person who insists on taking alcohol and yet should be treated for depression is often administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another gang of anti-depressants (like tricyclics) could cause a brand new symptom in such patients, which would require a various and expensive treatment. Therefore, it’s better to prescribe the more costly escitalopram rather than a cheaper tricyclic in these patients.
Simplicity of treatment: Most effective mode of administration is preferred. When there is an option between an injection and oral administration, aforementioned is preferred in the event the efficacy of the two modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic treatments for eye infections. Dosage and frequency of administration too are an important factor to determine simple treatment.
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