SINCE World War II, medical science has progressed with a stage where competitive medications are available to treat exactly the same ailment in various people. This is not nearly brands (the trade issue) but generic drugs (the scientific issue). On this report, we shall glance at the various factors that decide your selection of a certain drug.
Safety: The following sub-criteria has to be considered beneath the criterion of safety:
* Acute therapeutic index: If your patient’s condition is acute, how effective can be a particular drug even when it’s got certain side-effects provided that the acuteness from the condition is lowered? Example: narcotic pain-killers work well in healing pain but come with the possible side-effect of addiction.
* Long-term safety: medication directory could be safe in short-term treatment, but exactly how safe it’s in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but sometimes have undesirable effects in the case of prolonged use.
* Drug-drug interaction risk: Medicines are chemicals, and many chemicals react to create a different chemical, that have an effect that may harm the sufferer or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to produce a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from the other, have certain effects one or more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the act of a liver enzyme that Lexapro (escitalopram) depends on for the metabolism. This causes more the side-effects of Lexapro.
· Pharmacodynamic: Here, a couple of drugs actually create the same impact on exactly the same organ, thus helping the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly on the brain. Thus, the side-effects of both the prescription medication is more intense.
Tolerability: A medicine could be effective however, not tolerable by all patients. Example: Allergies to a particular drugs in certain people. Short-term and long-term tolerability should be taken into account. Efficacy: A medicine just isn’t equally great at all patients. For example, some patients with depression or anxiety disorders experience reduced escitalopram, but there are several who don’t, who therefore should be prescribed another anti-depressant. The pace of onset of therapeutic action is a key to be looked at too.
Cost: Cost doesn’t imply the cost of purchase of a certain medicine alone. It ought to also cover the cost of management of a complication that may arise from using another drug. Example: Within a one who insists on taking alcohol yet needs to be treated for depression is generally administered an SSRI drug because they drugs don’t potentiate the results of alcohol, whereas another group of anti-depressants (like tricyclics) may cause a brand new problem in such patients, which would have to have a various and expensive treatment. Therefore, it’s easier to prescribe the more expensive escitalopram instead of a cheaper tricyclic such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you have a selection between a shot and oral administration, rogues is preferred if the efficacy of both the modes is analogous. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key factor to determine simple treatment.
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