SINCE The second world war, medical science has progressed with a stage where competitive medications are around to treat exactly the same ailment in different people. This is not nearly brands (the industry trade issue) but generic drugs (the industry scientific issue). With this report, we shall look at the various factors that decide picking a a particular drug.
Safety: The next sub-criteria must be considered beneath the criterion of safety:
* Acute therapeutic index: When the patient’s condition is acute, how effective is a particular drug even if it has certain side-effects providing the acuteness from the condition is lowered? Example: narcotic pain-killers are very effective in healing pain but have the opportunity side-effect of addiction.
* Long-term safety: directory could possibly be safe in short-term treatment, but wait, how safe it is in long-term treatment? Example: antibiotics are acceptable in short-term treatment, but tend to have undesirable effects in case of prolonged use.
* Drug-drug interaction risk: Medicine is chemicals, and many chemicals respond to develop a different chemical, that have an effect which could harm the person or aggravate his/her condition. Example: A tricyclic anti-depressant and alcohol interact to create a new condition that warrants separate treatment.
Drug-drug interaction risk is of two types:
· Pharmacokinetic: In this kind of drug-drug interaction, two drugs, separate from each other, have certain effects on one or even more body processes (e.g., metabolism) that affects the performance from the other. Example: Darvocet-N (propoxyphene and acetaminophen) inhibits the action of a liver enzyme that Lexapro (escitalopram) depends on for its metabolism. This leads to more the side-effects of Lexapro.
· Pharmacodynamic: Here, 2 or more drugs actually generate the same relation to exactly the same organ, thus increasing the total, added effect. Example: Lexapro has certain side-effects like drowsiness and fatigue. Darvocet-N also acts similarly about the brain. Thus, the side-effects of both prescription medication is more intense.
Tolerability: A medicine could possibly be effective however, not tolerable by all patients. Example: Allergies to certain drugs in a few people. Short-term and long-term tolerability need to be taken into consideration. Efficacy: A medicine is just not equally great at all patients. For example, some patients with depression or anxiety disorders experience rest from escitalopram, but there are several who don’t, who therefore need to be prescribed a different anti-depressant. The rate of start of therapeutic action is an important the answer to be regarded as too.
Cost: Cost does not necessarily mean the price of purchase of some medicine alone. It must also cover the price of management of a complication which could arise from utilizing a different drug. Example: In the individual who insists on taking alcohol and yet must be treated for depression is usually administered an SSRI drug because they drugs don’t potentiate the end results of alcohol, whereas another number of anti-depressants (like tricyclics) can cause a fresh condition in such patients, which will have to have a various and expensive treatment. Therefore, it’s easier to prescribe the more costly escitalopram instead of a cheaper tricyclic in such patients.
Simplicity of treatment: The simplest mode of administration is preferred. If you have a selection between a shot and oral administration, rogues is preferred if your efficacy of both modes is the identical. Or, local application is chosen over the oral route where possible; e.g., antibiotic management of eye infections. Dosage and frequency of administration too are a key point to decide simple treatment.
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